diff --git a/refurb/checks/logical/use_in.py b/refurb/checks/logical/use_in.py
index 4e06f08..cad5e99 100644
--- a/refurb/checks/logical/use_in.py
+++ b/refurb/checks/logical/use_in.py
@@ -1,8 +1,26 @@
 from dataclasses import dataclass
 
-from mypy.nodes import OpExpr
-
-from refurb.checks.common import get_common_expr_in_comparison_chain
+from mypy.nodes import (
+    BytesExpr,
+    CallExpr,
+    ComparisonExpr,
+    ComplexExpr,
+    Expression,
+    FloatExpr,
+    IndexExpr,
+    IntExpr,
+    MemberExpr,
+    NameExpr,
+    OpExpr,
+    StrExpr,
+    UnaryExpr,
+)
+
+from refurb.checks.common import (
+    extract_binary_oper,
+    get_common_expr_in_comparison_chain,
+    get_common_expr_positions,
+)
 from refurb.error import Error
 
 
@@ -36,6 +54,52 @@ class ErrorInfo(Error):
     categories = ("logical", "readability")
 
 
+def _is_simple_expr(node: Expression) -> bool:
+    """
+    Check if an expression is simple enough to be safely eagerly evaluated.
+
+    Simple expressions are those that cannot raise exceptions or have side
+    effects when evaluated, making them safe for use in `in` tuple checks
+    where short-circuit evaluation is lost.
+    """
+    match node:
+        case NameExpr() | IntExpr() | StrExpr() | BytesExpr() | FloatExpr() | ComplexExpr():
+            return True
+
+        case MemberExpr(expr=expr):
+            return _is_simple_expr(expr)
+
+        case UnaryExpr(expr=expr):
+            return _is_simple_expr(expr)
+
+        case OpExpr(left=left, right=right):
+            return _is_simple_expr(left) and _is_simple_expr(right)
+
+        case IndexExpr() | CallExpr():
+            return False
+
+    return False  # pragma: no cover
+
+
+def _get_non_common_operands(node: OpExpr) -> list[Expression] | None:
+    """
+    Extract non-common operands from a comparison chain.
+
+    Given `a == b or c == d` where some operands are common,
+    returns the non-common operands (those that would be eagerly
+    evaluated in an `in` tuple).
+    """
+    match extract_binary_oper("or", node):
+        case (
+            ComparisonExpr(operators=[lhs_oper], operands=[a, b]),
+            ComparisonExpr(operators=[rhs_oper], operands=[c, d]),
+        ) if lhs_oper == rhs_oper == "==" and (indices := get_common_expr_positions(a, b, c, d)):
+            operands = [a, b, c, d]
+            return [op for i, op in enumerate(operands) if i not in indices]
+
+    return None  # pragma: no cover
+
+
 def create_message(indices: tuple[int, int]) -> str:
     names = ["x", "y", "z"]
     common_name = names[indices[0]]
@@ -53,4 +117,8 @@ def check(node: OpExpr, errors: list[Error]) -> None:
     if data := get_common_expr_in_comparison_chain(node, oper="or"):
         expr, indices = data
 
+        non_common = _get_non_common_operands(node)
+        if non_common is not None and not all(_is_simple_expr(op) for op in non_common):
+            return
+
         errors.append(ErrorInfo.from_node(expr, create_message(indices)))
diff --git a/test/data/err_108.py b/test/data/err_108.py
index 5f19491..310363a 100644
--- a/test/data/err_108.py
+++ b/test/data/err_108.py
@@ -22,7 +22,22 @@ class C:
 _ = "abc" == x or "def" == x
 _ = "abc" == x or x == "def"
 
+# simple compound expressions should still match
+_ = x == c.y or x == "def"
+_ = x == -1 or x == 1
+a = 1
+b = 2
+_ = x == a + b or x == "def"
+
 # these should not
 
 _ = x == "abc" or y == "def"
 _ = x == "abc" or x == "def" and y == "ghi"
+
+# short-circuit dependent expressions should not match (see #350)
+events = [1, 2, 3]
+cutoff = 0
+_ = cutoff == 0 or events[cutoff - 1] == 0
+d = {"a": 1}
+_ = x == "abc" or x == d["a"]
+_ = x == len(x) or x == "abc"
diff --git a/test/data/err_108.txt b/test/data/err_108.txt
index 81f89a1..af9d911 100644
--- a/test/data/err_108.txt
+++ b/test/data/err_108.txt
@@ -7,3 +7,6 @@ test/data/err_108.py:17:5 [FURB108]: Replace `x == y or x == z` with `x in (y, z
 test/data/err_108.py:21:5 [FURB108]: Replace `x == y or z == x` with `x in (y, z)`
 test/data/err_108.py:22:5 [FURB108]: Replace `x == y or z == y` with `y in (x, z)`
 test/data/err_108.py:23:5 [FURB108]: Replace `x == y or y == z` with `y in (x, z)`
+test/data/err_108.py:26:5 [FURB108]: Replace `x == y or x == z` with `x in (y, z)`
+test/data/err_108.py:27:5 [FURB108]: Replace `x == y or x == z` with `x in (y, z)`
+test/data/err_108.py:30:5 [FURB108]: Replace `x == y or x == z` with `x in (y, z)`