diff --git a/mypy.ini b/mypy.ini
index e36c23ebbc8a..a6f8d17f0ab3 100644
--- a/mypy.ini
+++ b/mypy.ini
@@ -14,7 +14,6 @@ exclude = (?x)(
   | (^|/)tests/unit/gapic/
   )
 
-
 # ==============================================================================
 # GLOBAL THIRD-PARTY & SHARED LIBRARY IGNORES
 # ==============================================================================
@@ -28,13 +27,7 @@ ignore_missing_imports = True
 [mypy-flask]
 ignore_missing_imports = True
 
-[mypy-google.auth.*]
-ignore_missing_imports = True
-
-[mypy-google.cloud.bigtable]
-ignore_missing_imports = True
-
-[mypy-google.cloud.pubsub]
+[mypy-google.api.*]
 ignore_missing_imports = True
 
 [mypy-google.colab]
@@ -61,6 +54,9 @@ ignore_missing_imports = True
 [mypy-grpc.*]
 ignore_missing_imports = True
 
+[mypy-grpc_status]
+ignore_missing_imports = True
+
 [mypy-ibis.*]
 ignore_missing_imports = True
 
@@ -86,15 +82,47 @@ ignore_missing_imports = True
 # ==============================================================================
 # PACKAGE-SPECIFIC OVERRIDES & EXCEPTIONS
 # ==============================================================================
+# --- bigframes ---
+[mypy-bigframes_vendored.*]
+ignore_errors = True
+
+# --- google-auth ---
+[mypy-google.auth.*]
+ignore_missing_imports = True
 
 # --- google-cloud-bigtable ---
-[mypy-google.cloud.bigtable.*]
-ignore_errors = True
+[mypy-google.cloud.bigtable]
+ignore_missing_imports = True
 
-[mypy-google.cloud.bigtable.data.*]
+[mypy-google.cloud.bigtable.*]
 check_untyped_defs = True
 warn_unreachable = True
 disallow_any_generics = True
+ignore_errors = True
+
+[mypy-google.cloud.bigtable.data.*]
 ignore_errors = False
 
+[mypy-google.cloud.bigtable_admin.*]
+ignore_errors = True
+
+[mypy-google.cloud.bigtable_admin_v2.*]
+ignore_errors = True
+
+[mypy-google.cloud.bigtable_v2.*]
+ignore_errors = True
+
+# --- google-cloud-datastore ---
+[mypy-google.cloud.datastore.*]
+ignore_missing_imports = True
+
+[mypy-google.cloud.datastore._app_engine_key_pb2]
+ignore_errors = True
 
+# --- google-cloud-firestore ---
+[mypy-google.cloud.firestore.*]
+check_untyped_defs = True
+
+# --- google-cloud-pubsub ---
+[mypy-google.cloud.pubsub]
+ignore_missing_imports = True
diff --git a/packages/bigquery-magics/mypy.ini b/packages/bigquery-magics/mypy.ini
deleted file mode 100644
index a3cb5c292172..000000000000
--- a/packages/bigquery-magics/mypy.ini
+++ /dev/null
@@ -1,3 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
diff --git a/packages/bigquery-magics/noxfile.py b/packages/bigquery-magics/noxfile.py
index f275406b6905..0ff22a1037e7 100644
--- a/packages/bigquery-magics/noxfile.py
+++ b/packages/bigquery-magics/noxfile.py
@@ -112,6 +112,17 @@
 }
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 nox.options.sessions = [
     "unit",
diff --git a/packages/db-dtypes/noxfile.py b/packages/db-dtypes/noxfile.py
index b80b1df6832a..afd1ab00a637 100644
--- a/packages/db-dtypes/noxfile.py
+++ b/packages/db-dtypes/noxfile.py
@@ -70,6 +70,17 @@
 SYSTEM_TEST_EXTRAS_BY_PYTHON: Dict[str, List[str]] = {}
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 # 'docfx' is excluded since it only needs to run in 'docs-presubmit'
 nox.options.sessions = [
@@ -541,6 +552,7 @@ def mypy(session):
     session.install("-e", ".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "db_dtypes",
         "--check-untyped-defs",
diff --git a/packages/django-google-spanner/noxfile.py b/packages/django-google-spanner/noxfile.py
index 0b94e5b87bff..dfdeaa49f4a1 100644
--- a/packages/django-google-spanner/noxfile.py
+++ b/packages/django-google-spanner/noxfile.py
@@ -66,6 +66,16 @@
 ]
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
diff --git a/packages/gapic-generator/mypy.ini b/packages/gapic-generator/mypy.ini
deleted file mode 100644
index ecb455a69d99..000000000000
--- a/packages/gapic-generator/mypy.ini
+++ /dev/null
@@ -1,2 +0,0 @@
-[mypy]
-python_version = 3.14
diff --git a/packages/gapic-generator/noxfile.py b/packages/gapic-generator/noxfile.py
index 6fac5c48853d..a9b1d7fc5bf7 100644
--- a/packages/gapic-generator/noxfile.py
+++ b/packages/gapic-generator/noxfile.py
@@ -36,6 +36,18 @@
 
 showcase_version = os.environ.get("SHOWCASE_VERSION", "0.35.0")
 ADS_TEMPLATES = path.join(path.dirname(__file__), "gapic", "ads-templates")
+CURRENT_DIRECTORY = Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 RUFF_VERSION = "ruff==0.14.14"
 LINT_PATHS = ["docs", "gapic", "tests", "test_utils", "noxfile.py", "setup.py"]
 # Ruff uses globs for excludes (different from Black's regex)
@@ -714,7 +726,7 @@ def mypy(session):
         "click==8.1.3",
     )
     session.install(".")
-    session.run("mypy", "-p", "gapic")
+    session.run("mypy", f"--config-file={MYPY_CONFIG_FILE}", "-p", "gapic")
 
 
 @nox.session(python=NEWEST_PYTHON)
@@ -726,7 +738,7 @@ def lint(session):
     """
 
     # TODO(https://github.com/googleapis/google-cloud-python/issues/16186):
-    # SKIP: This session was not enforced in the standalone (split) repo 
+    # SKIP: This session was not enforced in the standalone (split) repo
     # and is disabled here to ensure a "move-only" migration.
     session.skip(
         "Linting was not enforced in the split repo. "
@@ -756,9 +768,11 @@ def lint(session):
 @nox.session(python=NEWEST_PYTHON)
 def lint_setup_py(session):
     # TODO(https://github.com/googleapis/google-cloud-python/issues/16186):
-    # SKIP: This session was not enforced in the standalone (split) repo 
+    # SKIP: This session was not enforced in the standalone (split) repo
     # and is disabled here to ensure a "move-only" migration.
-    session.skip("Skipping now to avoid changing code during migration. See Issue #16186")
+    session.skip(
+        "Skipping now to avoid changing code during migration. See Issue #16186"
+    )
 
 
 @nox.session(python="3.10")
@@ -833,9 +847,11 @@ def prerelease_deps(session, protobuf_implementation):
     """
     Run all tests with pre-release versions of dependencies installed.
     """
-    # TODO(https://github.com/googleapis/google-cloud-python/issues/16184): 
+    # TODO(https://github.com/googleapis/google-cloud-python/issues/16184):
     # Implement pre-release dependency logic to test against upcoming runtime changes.
-    session.skip("prerelease_deps session is not yet implemented for gapic-generator-python.")
+    session.skip(
+        "prerelease_deps session is not yet implemented for gapic-generator-python."
+    )
 
 
 @nox.session(python=NEWEST_PYTHON)
@@ -845,6 +861,8 @@ def prerelease_deps(session, protobuf_implementation):
 )
 def core_deps_from_source(session, protobuf_implementation):
     """Run all tests with core dependencies installed from source."""
-    # TODO(https://github.com/googleapis/google-cloud-python/issues/16185): 
+    # TODO(https://github.com/googleapis/google-cloud-python/issues/16185):
     # Implement logic to install core packages directly from the mono-repo directories.
-    session.skip("core_deps_from_source session is not yet implemented for gapic-generator-python.")
\ No newline at end of file
+    session.skip(
+        "core_deps_from_source session is not yet implemented for gapic-generator-python."
+    )
diff --git a/packages/gcp-sphinx-docfx-yaml/noxfile.py b/packages/gcp-sphinx-docfx-yaml/noxfile.py
index ba5658c0e24f..c83da80f1973 100644
--- a/packages/gcp-sphinx-docfx-yaml/noxfile.py
+++ b/packages/gcp-sphinx-docfx-yaml/noxfile.py
@@ -13,11 +13,24 @@
 # limitations under the License.
 
 import os
+import pathlib
 
 import nox
 
 DEFAULT_PYTHON_VERSION = "3.14"
 UNIT_TEST_PYTHON_VERSIONS = ["3.8", "3.9", "3.10", "3.11", "3.12", "3.13", "3.14"]
+CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 RUFF_VERSION = "ruff==0.14.14"
 
 ALL_PYTHON = list(UNIT_TEST_PYTHON_VERSIONS)
diff --git a/packages/google-api-core/noxfile.py b/packages/google-api-core/noxfile.py
index 0bad668a80dd..c2904cfc0261 100644
--- a/packages/google-api-core/noxfile.py
+++ b/packages/google-api-core/noxfile.py
@@ -39,6 +39,16 @@
 
 DEFAULT_PYTHON_VERSION = "3.14"
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
 
 
 # Error if a python version is missing
@@ -370,7 +380,7 @@ def mypy(session):
         "types-requests",
         "types-protobuf",
     )
-    session.run("mypy", "google", "tests")
+    session.run("mypy", f"--config-file={MYPY_CONFIG_FILE}", "google", "tests")
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
diff --git a/packages/google-auth-httplib2/noxfile.py b/packages/google-auth-httplib2/noxfile.py
index 67b1bd420cc5..162301d4f13b 100644
--- a/packages/google-auth-httplib2/noxfile.py
+++ b/packages/google-auth-httplib2/noxfile.py
@@ -69,6 +69,17 @@
 SYSTEM_TEST_EXTRAS_BY_PYTHON: Dict[str, List[str]] = {}
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 # Error if a python version is missing
 nox.options.error_on_missing_interpreters = True
@@ -101,6 +112,7 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "google_auth_httplib2.py",
     )
 
diff --git a/packages/google-auth-oauthlib/noxfile.py b/packages/google-auth-oauthlib/noxfile.py
index a028eb1f1900..1a7f043e7461 100644
--- a/packages/google-auth-oauthlib/noxfile.py
+++ b/packages/google-auth-oauthlib/noxfile.py
@@ -69,6 +69,17 @@
 SYSTEM_TEST_EXTRAS_BY_PYTHON: Dict[str, List[str]] = {}
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 # Error if a python version is missing
 nox.options.error_on_missing_interpreters = True
@@ -471,6 +482,7 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google_auth_oauthlib",
     )
diff --git a/packages/google-auth/mypy.ini b/packages/google-auth/mypy.ini
deleted file mode 100644
index c129006db138..000000000000
--- a/packages/google-auth/mypy.ini
+++ /dev/null
@@ -1,3 +0,0 @@
-[mypy]
-python_version = 3.9
-namespace_packages = True
diff --git a/packages/google-auth/noxfile.py b/packages/google-auth/noxfile.py
index 5962f96bf094..a7a2bf17e1de 100644
--- a/packages/google-auth/noxfile.py
+++ b/packages/google-auth/noxfile.py
@@ -20,6 +20,17 @@
 import nox
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 CLICK_VERSION = "click"
 BLACK_VERSION = "black==23.7.0"
@@ -156,7 +167,16 @@ def mypy(session):
         "types-mock",
         "pytest<8.0.0",
     )
-    session.run("mypy", "-p", "google", "-p", "tests", "-p", "tests_async")
+    session.run(
+        "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
+        "-p",
+        "google",
+        "-p",
+        "tests",
+        "-p",
+        "tests_async",
+    )
 
 
 @nox.session(python=ALL_PYTHON)
diff --git a/packages/google-cloud-bigquery/mypy.ini b/packages/google-cloud-bigquery/mypy.ini
deleted file mode 100644
index a3cb5c292172..000000000000
--- a/packages/google-cloud-bigquery/mypy.ini
+++ /dev/null
@@ -1,3 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
diff --git a/packages/google-cloud-bigquery/noxfile.py b/packages/google-cloud-bigquery/noxfile.py
index c1dd1692b744..d4accfea91a4 100644
--- a/packages/google-cloud-bigquery/noxfile.py
+++ b/packages/google-cloud-bigquery/noxfile.py
@@ -41,6 +41,17 @@
 ALL_PYTHON = ["3.10", "3.11", "3.12", "3.13", "3.14"]
 UNIT_TEST_PYTHON_VERSIONS = ALL_PYTHON
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 SYSTEM_TEST_PYTHON_VERSIONS = UNIT_TEST_PYTHON_VERSIONS
 
@@ -215,7 +226,13 @@ def mypy(session):
     )
     session.run("python", "-m", "pip", "freeze")
     with log_package_context(session):
-        session.run("mypy", "-p", "google", "--show-traceback")
+        session.run(
+            "mypy",
+            f"--config-file={MYPY_CONFIG_FILE}",
+            "-p",
+            "google",
+            "--show-traceback",
+        )
 
 
 @nox.session(python=SYSTEM_TEST_PYTHON_VERSIONS)
diff --git a/packages/google-cloud-bigtable/mypy.ini b/packages/google-cloud-bigtable/mypy.ini
deleted file mode 100644
index 701b7587ce6f..000000000000
--- a/packages/google-cloud-bigtable/mypy.ini
+++ /dev/null
@@ -1,38 +0,0 @@
-[mypy]
-python_version = 3.13
-namespace_packages = True
-check_untyped_defs = True
-warn_unreachable = True
-disallow_any_generics = True
-exclude = tests/unit/gapic/
-
-[mypy-grpc.*]
-ignore_missing_imports = True
-
-[mypy-google.auth.*]
-ignore_missing_imports = True
-
-[mypy-google.iam.*]
-ignore_missing_imports = True
-
-[mypy-google.longrunning.*]
-ignore_missing_imports = True
-
-[mypy-google.oauth2.*]
-ignore_missing_imports = True
-
-[mypy-google.rpc.*]
-ignore_missing_imports = True
-
-[mypy-proto.*]
-ignore_missing_imports = True
-
-[mypy-pytest]
-ignore_missing_imports = True
-
-[mypy-google.cloud.*]
-ignore_errors = True
-
-# only verify data client
-[mypy-google.cloud.bigtable.data.*]
-ignore_errors = False
diff --git a/packages/google-cloud-bigtable/noxfile.py b/packages/google-cloud-bigtable/noxfile.py
index e6ef8c1e9911..25b94d7b6ab4 100644
--- a/packages/google-cloud-bigtable/noxfile.py
+++ b/packages/google-cloud-bigtable/noxfile.py
@@ -66,6 +66,17 @@
 SYSTEM_TEST_EXTRAS_BY_PYTHON: Dict[str, List[str]] = {}
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 # 'docfx' is excluded since it only needs to run in 'docs-presubmit'
 nox.options.sessions = [
@@ -175,7 +186,9 @@ def mypy(session):
         "types-requests",
     )
     session.install("google-cloud-testutils")
-    session.run("mypy", "-p", "google.cloud.bigtable.data")
+    session.run(
+        "mypy", f"--config-file={MYPY_CONFIG_FILE}", "-p", "google.cloud.bigtable.data"
+    )
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
diff --git a/packages/google-cloud-core/mypy.ini b/packages/google-cloud-core/mypy.ini
deleted file mode 100644
index ed9dccd3b6fd..000000000000
--- a/packages/google-cloud-core/mypy.ini
+++ /dev/null
@@ -1,7 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
-ignore_missing_imports = True
-
-[mypy-google.protobuf]
-ignore_missing_imports = True
diff --git a/packages/google-cloud-core/noxfile.py b/packages/google-cloud-core/noxfile.py
index 2de40dfb9234..a86e71252c69 100644
--- a/packages/google-cloud-core/noxfile.py
+++ b/packages/google-cloud-core/noxfile.py
@@ -15,6 +15,7 @@
 from __future__ import absolute_import
 
 import os
+import pathlib
 import re
 import shutil
 
@@ -32,7 +33,17 @@
     "3.13",
     "3.14",
 ]
-CURRENT_DIRECTORY = os.path.abspath(os.path.dirname(__file__))
+CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
 
 # Error if a python version is missing
 nox.options.error_on_missing_interpreters = True
@@ -62,7 +73,14 @@ def mypy(session):
         "types-mock",
         "types-protobuf!=4.24.0.20240106",
     )
-    session.run("mypy", "-p", "google", "-p", "tests")
+    session.run(
+        "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
+        "-p",
+        "google",
+        "-p",
+        "tests",
+    )
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
diff --git a/packages/google-cloud-datastore/mypy.ini b/packages/google-cloud-datastore/mypy.ini
deleted file mode 100644
index 2d553926db9d..000000000000
--- a/packages/google-cloud-datastore/mypy.ini
+++ /dev/null
@@ -1,23 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
-ignore_missing_imports = True
-
-# Helps mypy navigate the 'google' namespace more reliably in 3.10+
-explicit_package_bases = True
-
-# Performance: reuse results from previous runs to speed up "nox"
-incremental = True
-
-[mypy-google.cloud.datastore._app_engine_key_pb2]
-ignore_errors = True
-
-# TODO(https://github.com/googleapis/gapic-generator-python/issues/2410):
-# Remove once this generator bug is fixed
-[mypy-google.cloud.datastore_v1.services.datastore.async_client]
-ignore_errors = True
-
-# TODO(https://github.com/googleapis/gapic-generator-python/issues/2410):
-# Remove once this generator bug is fixed
-[mypy-google.cloud.datastore_v1.services.datastore.client]
-ignore_errors = True
diff --git a/packages/google-cloud-datastore/noxfile.py b/packages/google-cloud-datastore/noxfile.py
index af42d740478e..d803e9759965 100644
--- a/packages/google-cloud-datastore/noxfile.py
+++ b/packages/google-cloud-datastore/noxfile.py
@@ -46,6 +46,17 @@
 PREVIEW_PYTHON_VERSION = "3.14"
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 if (CURRENT_DIRECTORY / "testing").exists():
     LOWER_BOUND_CONSTRAINTS_FILE = (
@@ -107,6 +118,7 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google",
         # TODO(https://github.com/googleapis/google-cloud-python/issues/16083)
diff --git a/packages/google-cloud-dns/noxfile.py b/packages/google-cloud-dns/noxfile.py
index bb38d1e08a91..55c042e6b68f 100644
--- a/packages/google-cloud-dns/noxfile.py
+++ b/packages/google-cloud-dns/noxfile.py
@@ -67,6 +67,17 @@
 SYSTEM_TEST_EXTRAS_BY_PYTHON: Dict[str, List[str]] = {}
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 nox.options.sessions = [
     "unit-3.10",
@@ -155,6 +166,7 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google",
     )
diff --git a/packages/google-cloud-documentai-toolbox/noxfile.py b/packages/google-cloud-documentai-toolbox/noxfile.py
index db70716c5d6b..d046a6f3d39b 100644
--- a/packages/google-cloud-documentai-toolbox/noxfile.py
+++ b/packages/google-cloud-documentai-toolbox/noxfile.py
@@ -69,6 +69,17 @@
 SYSTEM_TEST_EXTRAS_BY_PYTHON: Dict[str, List[str]] = {}
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 nox.options.sessions = [
     "unit-3.10",
@@ -498,6 +509,7 @@ def mypy(session):
     session.install("-e", ".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google.cloud.documentai_toolbox",
         "--check-untyped-defs",
diff --git a/packages/google-cloud-error-reporting/mypy.ini b/packages/google-cloud-error-reporting/mypy.ini
deleted file mode 100644
index e0e0da2e9e40..000000000000
--- a/packages/google-cloud-error-reporting/mypy.ini
+++ /dev/null
@@ -1,15 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
-ignore_missing_imports = False
-
-# TODO(https://github.com/googleapis/gapic-generator-python/issues/2563):
-# Dependencies that historically lacks py.typed markers
-[mypy-google.iam.*]
-ignore_missing_imports = True
-
-# Helps mypy navigate the 'google' namespace more reliably in 3.10+
-explicit_package_bases = True
-
-# Performance: reuse results from previous runs to speed up 'nox'
-incremental = True
diff --git a/packages/google-cloud-error-reporting/noxfile.py b/packages/google-cloud-error-reporting/noxfile.py
index e13108291d94..9c99c1dbc424 100644
--- a/packages/google-cloud-error-reporting/noxfile.py
+++ b/packages/google-cloud-error-reporting/noxfile.py
@@ -46,6 +46,17 @@
 PREVIEW_PYTHON_VERSION = "3.14"
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 if (CURRENT_DIRECTORY / "testing").exists():
     LOWER_BOUND_CONSTRAINTS_FILE = (
@@ -107,6 +118,7 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google",
         # TODO(https://github.com/googleapis/google-cloud-python/issues/16083)
diff --git a/packages/google-cloud-firestore/mypy.ini b/packages/google-cloud-firestore/mypy.ini
deleted file mode 100644
index e0e0da2e9e40..000000000000
--- a/packages/google-cloud-firestore/mypy.ini
+++ /dev/null
@@ -1,15 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
-ignore_missing_imports = False
-
-# TODO(https://github.com/googleapis/gapic-generator-python/issues/2563):
-# Dependencies that historically lacks py.typed markers
-[mypy-google.iam.*]
-ignore_missing_imports = True
-
-# Helps mypy navigate the 'google' namespace more reliably in 3.10+
-explicit_package_bases = True
-
-# Performance: reuse results from previous runs to speed up 'nox'
-incremental = True
diff --git a/packages/google-cloud-firestore/noxfile.py b/packages/google-cloud-firestore/noxfile.py
index 4df37240719c..56ef7dcac0d5 100644
--- a/packages/google-cloud-firestore/noxfile.py
+++ b/packages/google-cloud-firestore/noxfile.py
@@ -46,6 +46,17 @@
 PREVIEW_PYTHON_VERSION = "3.14"
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 if (CURRENT_DIRECTORY / "testing").exists():
     LOWER_BOUND_CONSTRAINTS_FILE = (
@@ -166,9 +177,9 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google",
-        "--check-untyped-defs",
         *session.posargs,
     )
 
diff --git a/packages/google-cloud-logging/mypy.ini b/packages/google-cloud-logging/mypy.ini
deleted file mode 100644
index e0e0da2e9e40..000000000000
--- a/packages/google-cloud-logging/mypy.ini
+++ /dev/null
@@ -1,15 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
-ignore_missing_imports = False
-
-# TODO(https://github.com/googleapis/gapic-generator-python/issues/2563):
-# Dependencies that historically lacks py.typed markers
-[mypy-google.iam.*]
-ignore_missing_imports = True
-
-# Helps mypy navigate the 'google' namespace more reliably in 3.10+
-explicit_package_bases = True
-
-# Performance: reuse results from previous runs to speed up 'nox'
-incremental = True
diff --git a/packages/google-cloud-logging/noxfile.py b/packages/google-cloud-logging/noxfile.py
index f243539c2d21..2f8d10e8342f 100644
--- a/packages/google-cloud-logging/noxfile.py
+++ b/packages/google-cloud-logging/noxfile.py
@@ -46,6 +46,17 @@
 PREVIEW_PYTHON_VERSION = "3.14"
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 if (CURRENT_DIRECTORY / "testing").exists():
     LOWER_BOUND_CONSTRAINTS_FILE = (
diff --git a/packages/google-cloud-ndb/noxfile.py b/packages/google-cloud-ndb/noxfile.py
index e447badd711c..93564ffa28e0 100644
--- a/packages/google-cloud-ndb/noxfile.py
+++ b/packages/google-cloud-ndb/noxfile.py
@@ -31,6 +31,17 @@
 DEFAULT_INTERPRETER = "3.14"
 ALL_INTERPRETERS = ("3.10", "3.11", "3.12", "3.13", "3.14")
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 BLACK_VERSION = "black[jupyter]==23.7.0"
 RUFF_VERSION = "ruff==0.14.14"
@@ -535,6 +546,7 @@ def mypy(session):
     session.install("-e", ".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google.cloud.ndb",
         "--check-untyped-defs",
diff --git a/packages/google-cloud-pubsub/mypy.ini b/packages/google-cloud-pubsub/mypy.ini
deleted file mode 100644
index e0e0da2e9e40..000000000000
--- a/packages/google-cloud-pubsub/mypy.ini
+++ /dev/null
@@ -1,15 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
-ignore_missing_imports = False
-
-# TODO(https://github.com/googleapis/gapic-generator-python/issues/2563):
-# Dependencies that historically lacks py.typed markers
-[mypy-google.iam.*]
-ignore_missing_imports = True
-
-# Helps mypy navigate the 'google' namespace more reliably in 3.10+
-explicit_package_bases = True
-
-# Performance: reuse results from previous runs to speed up 'nox'
-incremental = True
diff --git a/packages/google-cloud-pubsub/noxfile.py b/packages/google-cloud-pubsub/noxfile.py
index fb01bc8d1105..f6f697a38073 100644
--- a/packages/google-cloud-pubsub/noxfile.py
+++ b/packages/google-cloud-pubsub/noxfile.py
@@ -86,6 +86,17 @@
 SYSTEM_TEST_EXTRAS_BY_PYTHON: Dict[str, List[str]] = {}
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 nox.options.sessions = [
     "unit",
@@ -133,7 +144,7 @@ def mypy(session):
     # mypy checks yet.
     # https://github.com/googleapis/gapic-generator-python/issues/1092
     # TODO: Re-enable mypy checks once we merge, since incremental checks are failing due to protobuf upgrade
-    # session.run("mypy", "-p", "google.cloud", "--exclude", "google/pubsub_v1/")
+    # session.run("mypy", f"--config-file={MYPY_CONFIG_FILE}", "-p", "google.cloud", "--exclude", "google/pubsub_v1/")
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
diff --git a/packages/google-cloud-runtimeconfig/noxfile.py b/packages/google-cloud-runtimeconfig/noxfile.py
index 42e77572607e..f4e52787ebf7 100644
--- a/packages/google-cloud-runtimeconfig/noxfile.py
+++ b/packages/google-cloud-runtimeconfig/noxfile.py
@@ -68,6 +68,17 @@
 SYSTEM_TEST_EXTRAS_BY_PYTHON: Dict[str, List[str]] = {}
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 # Error if a python version is missing
 nox.options.error_on_missing_interpreters = True
@@ -100,6 +111,7 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google",
     )
diff --git a/packages/google-cloud-spanner-dbapi-driver/mypy.ini b/packages/google-cloud-spanner-dbapi-driver/mypy.ini
deleted file mode 100644
index 81b11c94badc..000000000000
--- a/packages/google-cloud-spanner-dbapi-driver/mypy.ini
+++ /dev/null
@@ -1,15 +0,0 @@
-[mypy]
-python_version = 3.11
-namespace_packages = True
-ignore_missing_imports = False
-
-# TODO(https://github.com/googleapis/gapic-generator-python/issues/2563):
-# Dependencies that historically lacks py.typed markers
-[mypy-google.iam.*]
-ignore_missing_imports = True
-
-# Helps mypy navigate the 'google' namespace more reliably in 3.10+
-explicit_package_bases = True
-
-# Performance: reuse results from previous runs to speed up 'nox'
-incremental = True
diff --git a/packages/google-cloud-spanner-dbapi-driver/noxfile.py b/packages/google-cloud-spanner-dbapi-driver/noxfile.py
index 2fedee7ee5af..6eb00ef8a6b6 100644
--- a/packages/google-cloud-spanner-dbapi-driver/noxfile.py
+++ b/packages/google-cloud-spanner-dbapi-driver/noxfile.py
@@ -53,6 +53,17 @@
 PREVIEW_PYTHON_VERSION = "3.14"
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 LOWER_BOUND_CONSTRAINTS_FILE = CURRENT_DIRECTORY / "constraints.txt"
 PACKAGE_NAME = "google-cloud-spanner-dbapi-driver"
@@ -115,6 +126,7 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google",
     )
diff --git a/packages/google-cloud-spanner/mypy.ini b/packages/google-cloud-spanner/mypy.ini
deleted file mode 100644
index e0e0da2e9e40..000000000000
--- a/packages/google-cloud-spanner/mypy.ini
+++ /dev/null
@@ -1,15 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
-ignore_missing_imports = False
-
-# TODO(https://github.com/googleapis/gapic-generator-python/issues/2563):
-# Dependencies that historically lacks py.typed markers
-[mypy-google.iam.*]
-ignore_missing_imports = True
-
-# Helps mypy navigate the 'google' namespace more reliably in 3.10+
-explicit_package_bases = True
-
-# Performance: reuse results from previous runs to speed up 'nox'
-incremental = True
diff --git a/packages/google-cloud-spanner/noxfile.py b/packages/google-cloud-spanner/noxfile.py
index fa74716b8142..7dcb31b45ed7 100644
--- a/packages/google-cloud-spanner/noxfile.py
+++ b/packages/google-cloud-spanner/noxfile.py
@@ -69,6 +69,17 @@
 SYSTEM_TEST_EXTRAS_BY_PYTHON: Dict[str, List[str]] = {}
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 nox.options.sessions = [
     "unit-3.10",
@@ -767,6 +778,7 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google",
         # "--check-untyped-defs",
diff --git a/packages/google-cloud-storage/mypy.ini b/packages/google-cloud-storage/mypy.ini
deleted file mode 100644
index e0e0da2e9e40..000000000000
--- a/packages/google-cloud-storage/mypy.ini
+++ /dev/null
@@ -1,15 +0,0 @@
-[mypy]
-python_version = 3.14
-namespace_packages = True
-ignore_missing_imports = False
-
-# TODO(https://github.com/googleapis/gapic-generator-python/issues/2563):
-# Dependencies that historically lacks py.typed markers
-[mypy-google.iam.*]
-ignore_missing_imports = True
-
-# Helps mypy navigate the 'google' namespace more reliably in 3.10+
-explicit_package_bases = True
-
-# Performance: reuse results from previous runs to speed up 'nox'
-incremental = True
diff --git a/packages/google-cloud-storage/noxfile.py b/packages/google-cloud-storage/noxfile.py
index 6e8d41c60b3d..18ef45502ca8 100644
--- a/packages/google-cloud-storage/noxfile.py
+++ b/packages/google-cloud-storage/noxfile.py
@@ -46,6 +46,17 @@
 PREVIEW_PYTHON_VERSION = "3.14"
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 if (CURRENT_DIRECTORY / "testing").exists():
     LOWER_BOUND_CONSTRAINTS_FILE = (
diff --git a/packages/google-cloud-testutils/mypy.ini b/packages/google-cloud-testutils/mypy.ini
deleted file mode 100644
index 569486a9ce60..000000000000
--- a/packages/google-cloud-testutils/mypy.ini
+++ /dev/null
@@ -1,3 +0,0 @@
-[mypy]
-python_version = 3.10
-exclude = tests/unit/resources/
diff --git a/packages/google-cloud-testutils/noxfile.py b/packages/google-cloud-testutils/noxfile.py
index 0e86a298190e..caebbf8ef459 100644
--- a/packages/google-cloud-testutils/noxfile.py
+++ b/packages/google-cloud-testutils/noxfile.py
@@ -39,6 +39,16 @@
 RUFF_VERSION = "ruff==0.14.14"
 BLACK_PATHS = ["test_utils", "setup.py"]
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
 
 
 @nox.session(python=DEFAULT_PYTHON_VERSION)
@@ -80,8 +90,10 @@ def format(session):
 
     # 2. Run Ruff to fix imports
     session.run(
-        "ruff", "check",
-        "--select", "I",
+        "ruff",
+        "check",
+        "--select",
+        "I",
         "--fix",
         f"--target-version=py{ALL_PYTHON[0].replace('.', '')}",
         "--line-length=88",
@@ -90,7 +102,8 @@ def format(session):
 
     # 3. Run Ruff to format code
     session.run(
-        "ruff", "format",
+        "ruff",
+        "format",
         f"--target-version=py{ALL_PYTHON[0].replace('.', '')}",
         "--line-length=88",
         *BLACK_PATHS,
@@ -113,7 +126,7 @@ def mypy(session):
         "types-mock",
         "types-setuptools",
     )
-    session.run("mypy", "test_utils/", "tests/")
+    session.run("mypy", f"--config-file={MYPY_CONFIG_FILE}", "test_utils/", "tests/")
 
 
 @nox.session(python=ALL_PYTHON)
@@ -328,14 +341,12 @@ def prerelease_deps(session):
     )
 
 
-
 @nox.session(python=DEFAULT_PYTHON_VERSION)
 def core_deps_from_source(session):
     """Run all tests with core dependencies installed from source
     rather than pulling the dependencies from PyPI.
     """
 
-
     # Install all dependencies
     constraints_path = str(
         CURRENT_DIRECTORY / "testing" / f"constraints-{session.python}.txt"
diff --git a/packages/google-resumable-media/mypy.ini b/packages/google-resumable-media/mypy.ini
deleted file mode 100644
index 4505b485436b..000000000000
--- a/packages/google-resumable-media/mypy.ini
+++ /dev/null
@@ -1,3 +0,0 @@
-[mypy]
-python_version = 3.6
-namespace_packages = True
diff --git a/packages/google-resumable-media/noxfile.py b/packages/google-resumable-media/noxfile.py
index a1c1ae199709..6d0f35f30375 100644
--- a/packages/google-resumable-media/noxfile.py
+++ b/packages/google-resumable-media/noxfile.py
@@ -21,6 +21,17 @@
 import nox
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 SYSTEM_TEST_ENV_VARS = ("GOOGLE_APPLICATION_CREDENTIALS",)
 RUFF_VERSION = "ruff==0.14.14"
@@ -68,7 +79,7 @@ def unit(session):
         line_coverage,
         os.path.join("tests", "unit"),
         os.path.join("tests_async", "unit"),
-        *session.posargs
+        *session.posargs,
     )
 
 
@@ -106,6 +117,7 @@ def docs(session):
         os.path.join("docs", "_build", "html", ""),
     )
 
+
 @nox.session(python="3.10")
 def docfx(session):
     """Build the docfx yaml files for this library."""
@@ -251,7 +263,16 @@ def mypy(session):
         "types-requests",
         "types-mock",
     )
-    session.run("mypy", "-p", "google", "-p", "tests", "-p", "tests_async")
+    session.run(
+        "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
+        "-p",
+        "google",
+        "-p",
+        "tests",
+        "-p",
+        "tests_async",
+    )
 
 
 @nox.session(python=SYSTEM_TEST_PYTHON_VERSIONS)
@@ -319,7 +340,9 @@ def prerelease_deps(session):
     # version, the first version we test with in the unit tests sessions has a
     # constraints file containing all dependencies and extras.
     with open(
-        CURRENT_DIRECTORY / "testing" / f"constraints-{UNIT_TEST_PYTHON_VERSIONS[0]}.txt",
+        CURRENT_DIRECTORY
+        / "testing"
+        / f"constraints-{UNIT_TEST_PYTHON_VERSIONS[0]}.txt",
         encoding="utf-8",
     ) as constraints_file:
         constraints_text = constraints_file.read()
@@ -400,7 +423,9 @@ def core_deps_from_source(session):
     # version, the first version we test with in the unit tests sessions has a
     # constraints file containing all dependencies and extras.
     with open(
-        CURRENT_DIRECTORY / "testing" / f"constraints-{UNIT_TEST_PYTHON_VERSIONS[0]}.txt",
+        CURRENT_DIRECTORY
+        / "testing"
+        / f"constraints-{UNIT_TEST_PYTHON_VERSIONS[0]}.txt",
         encoding="utf-8",
     ) as constraints_file:
         constraints_text = constraints_file.read()
@@ -431,7 +456,9 @@ def core_deps_from_source(session):
     dep_paths = [str(deps_dir / dep) for dep in core_dependencies_from_source]
 
     session.install(*dep_paths, "--no-deps", "--ignore-installed")
-    print(f"Installed {', '.join(core_dependencies_from_source)} locally from {deps_dir}")
+    print(
+        f"Installed {', '.join(core_dependencies_from_source)} locally from {deps_dir}"
+    )
 
     other_deps = [
         "cryptography",
diff --git a/packages/pandas-gbq/noxfile.py b/packages/pandas-gbq/noxfile.py
index 8e58d09628bc..aabc6426becb 100644
--- a/packages/pandas-gbq/noxfile.py
+++ b/packages/pandas-gbq/noxfile.py
@@ -79,6 +79,17 @@
 SYSTEM_TEST_EXTRAS_BY_PYTHON = {}
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 # Error if a python version is missing
 nox.options.error_on_missing_interpreters = True
@@ -544,6 +555,7 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
+        f"--config-file={MYPY_CONFIG_FILE}",
         "pandas_gbq",
         "--check-untyped-defs",
         *session.posargs,
diff --git a/packages/proto-plus/noxfile.py b/packages/proto-plus/noxfile.py
index 4e07083cd49c..5ae48e61efd3 100644
--- a/packages/proto-plus/noxfile.py
+++ b/packages/proto-plus/noxfile.py
@@ -27,6 +27,17 @@
 LINT_PATHS = ["docs", "proto", "tests", "noxfile.py", "setup.py"]
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 
 DEFAULT_PYTHON_VERSION = "3.14"
 
diff --git a/packages/sqlalchemy-bigquery/noxfile.py b/packages/sqlalchemy-bigquery/noxfile.py
index b1e6b068c872..0588ec4893e2 100644
--- a/packages/sqlalchemy-bigquery/noxfile.py
+++ b/packages/sqlalchemy-bigquery/noxfile.py
@@ -119,6 +119,16 @@
 }
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
 
 
 def _calculate_duration(func):
diff --git a/packages/sqlalchemy-spanner/noxfile.py b/packages/sqlalchemy-spanner/noxfile.py
index 187d4e7e8924..7670ac29f936 100644
--- a/packages/sqlalchemy-spanner/noxfile.py
+++ b/packages/sqlalchemy-spanner/noxfile.py
@@ -82,6 +82,17 @@ class = StreamHandler
 RUFF_VERSION = "ruff==0.14.14"
 LINT_PATHS = ["google", "tests", "noxfile.py", "setup.py", "samples"]
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
+# Path to the centralized mypy configuration file at the repository root.
+# Search upwards to support running nox from both monorepo packages and integration test goldens.
+MYPY_CONFIG_FILE = next(
+    (
+        str(p / "mypy.ini")
+        for p in CURRENT_DIRECTORY.parents
+        if (p / "mypy.ini").exists()
+    ),
+    str(CURRENT_DIRECTORY.parent.parent / "mypy.ini"),
+)
+
 UNIT_TEST_STANDARD_DEPENDENCIES = [
     "mock",
     "pytest",